What additional symptom might support the diagnosis of infectious mononucleosis?

Fatigue and malaise are hallmark symptoms that often accompany infectious mononucleosis, which is primarily caused by the Epstein-Barr virus. Patients with this condition frequently report significant fatigue that can last for weeks, along with a general sense of malaise or unwellness. This symptom is especially relevant as it reflects the systemic nature of the infection, impacting the patient’s overall energy levels and well-being.

While other symptoms like high fever, rash, or neck pain might occur in some cases or in relation to different illnesses, fatigue and malaise are consistently present in infectious mononucleosis and help support its diagnosis. Recognizing this fatigue is essential for clinicians, as it aids in distinguishing infectious mononucleosis from other similar presentations, ultimately guiding appropriate management and care for the patient.